Effects of Intraoperative GDFT on the Postoperative Brain Edema (NCT03323580) | Clinical Trial Compass
CompletedNot Applicable
Effects of Intraoperative GDFT on the Postoperative Brain Edema
China480 participantsStarted 2018-11-26
Plain-language summary
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. To our knowledge, there has been no extensive and quantitative analysis of brain edema following SVV-based GDFT in neurosurgical patients with malignant supratentorial glioma. So the study aims to observe the effect of the stroke volume variation-based GDFT on the postoperative brain edema and decrease the incidence of postoperative complications in neurosurgical patients with malignant supratentorial gliomas.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. Preoperative brain image indicating high-grade glioma (HGG), verified by postoperative histology of the World Health Organization (WHO) as grade III or IV tumors.
✓. Age 18-65 years, and American Society of Anaesthesiologists (ASA) physical status I to III.
✓. Signed informed consent.
Exclusion criteria
✕. Renal insufficiency or the creatinine clearance is \< 30 mL/kg.
✕. Heart disease, New York Heart Association Functional Classification (NYHA) class II or higher heart failure, or if their cardiac ejection fraction is \< 20%.