Feasibility of Endovascular Repair of Ascending Aortic Pathologies (NCT03322033) | Clinical Trial Compass
TerminatedNot Applicable
Feasibility of Endovascular Repair of Ascending Aortic Pathologies
Stopped: Due to Medtronic no longer supporting the manufacturing of the custom/modified Valiant Captivia device required for the trial
United States1 participantsStarted 2018-12-15
Plain-language summary
The purpose of this early feasibility study is to investigate the outcome of selected patients with ascending thoracic aortic pathologies including type A aortic dissection, who are suitable for endovascular repair with the Medtronic Valiant PS-IDE Stent Graft System with the Captivia Delivery System (or the Valiant PS-IDE Stent Graft).
Who can participate
Age range21 Years
SexALL
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Inclusion Criteria:
* In order to qualify for this physician-sponsored Investigational Device Exemption, the patients would have to meet the entire entry criteria listed below, sign a consent approved by the FDA and IRB, and agrees to follow-up according to the study protocol.
* Patient must have a type A thoracic aortic dissection, retrograde type A thoracic aortic dissection of the ascending thoracic aorta affecting the area between the Sinus of Valsalva and the innominate artery orifice (with no involvement of the aortic valve) and be considered a candidate for endovascular repair;
* The proximal and distal landing zones for placement of graft should be at least 1 cm.
* The proximal landing zone will allow placement of the stent graft as to not inhibit valvular function, occlude a coronary ostium or proximal bypass graft; The aortic root may be dissected, but the proximal tear site must be at least 1cm from the STJ (and within the above listed size criteria).
* Distal landing zone must allow for continued perfusion of critical cerebral vessels;
* The aorta as measured adventitial wall to adventitial wall must be greater than 28 mm and no more than 44 mm maximum diameter at both the proximal and distal landing zone.
* The patient must be high-risk surgical candidate according to the following established criteria: ASA score of IV.
Exclusion Criteria:
* Pregnant or pediatric patients (younger than 21 years of age);
* Patients who have a condition t…
What they're measuring
1
Number of Participants With Freedom From Early Death