Benzo[a]Pyrene Ultralow Dose-Response Study

Inclusion Criteria: * Inclusion criteria for women: * Age 21-65 (inclusive) * Must be post-menopausal or have had surgical sterilization to eliminate any possibility for fetal exposure * Willing to defer blood donation for one month before, throughout, and one month after completion of study activities * Willing to avoid consuming cruciferous vegetables, I3C or DIM supplements, smoked or cured meat or cheeses, or charcoal-grilled meats for 2 weeks prior to and during each study cycle (gas grilled foods acceptable) Inclusion criteria for men: * Age 21-65 (inclusive) * Willing to defer blood donation for one month before, throughout, and one month after completion of study activities * Willing to avoid consuming cruciferous vegetables, I3C or DIM supplements, smoked or cured meat or cheeses, or charcoal-grilled meats for 2 weeks prior to and during each study cycle (gas grilled foods acceptable) Exclusion Criteria: Exclusion criteria for both men and women: * Smoker (tobacco or other substances) or use of smokeless tobacco in past 3 months or living with smoker * Regular use of medications that affect gut motility or nutrient absorption (e.g. cholestyramine, sucralfate, orlistat, pro- or anti-motility agents) * History of gastrointestinal surgery (e.g. bariatric surgery, cholecystectomy) or gastrointestinal disorder (Crohn's disease, celiac disease, IBS, or colitis) * Current or history of kidney or liver disease * Prior high-dose 14C exposure from medical tests.…