Nucleophilic Defense Against PM Toxicity (NEAT Trial)
United States299 participantsStarted 2018-04-01
Plain-language summary
Carnosine is a naturally occurring peptide found in high levels in skeletal muscle and the brain and is also available commercially as a dietary supplement. Since carnosine has anti-oxidant properties and air pollution exposure induces a state of oxidative stress, the purpose of this study is to see if those taking carnosine as a dietary supplement are protected from air pollution-induced oxidative stress and adverse cardiovascular outcomes.
Who can participate
Age range22 Years – 65 Years
SexALL
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Inclusion criteria
✓. Individuals between 22-65 years of age of either gender and all ethnicities,
✓. All genders and all ethnicities
✓. Residing in or near the Louisville metropolitan area
✓. Consumes some type of meat/fish at least once a month during the past 3 months
✓. Carnosine levels below the median level of the population
✓. Agrees to complete all study visits and follow study intervention regimen
✓. Will be living in the study area throughout the study period, with no more than 1 week away from the study area.
Exclusion criteria
✕. Consumed any dietary supplement more than 3 times per week in the past 4 weeks (one month)
✕. Current / ongoing treatment for substance abuse
✕. Currently undergoing treatment or have conditions which may cause participant to be immunosuppressed