Laparoscopic Surgery for T4 Tumor of the Colon Cancer (LST4C Trial)

Inclusion Criteria: * Able to provide written informed consent * Histologically confirmed diagnosis of colon carcinoma * CT or MRI verified as T4 colon cancer without involvement of other organs * Without multiple lesion other than carcinoma in situ * Tumor size \< 8 cm * No bowel obstruction * Sufficient organ function * No history of gastrointestinal surgery * 18 years of age or older * Performance Status (ECOG) 0, 1 or 2 and life expectancy \> 12 weeks * Operable patients Exclusion Criteria: * • Women who are pregnant (confirmed by serum b-HCG in women of reproductive age) or breast feeding * Unstable or uncompensated respiratory or cardiac disease * Serious active infections * Hypersensitivity to capecitabine/fluorouracil or oxaliplatin * Stomatitis, ulceration in the mouth or gastrointestinal tract * Severe diarrhea * Peripheral sensory neuropathy with functional impairment