The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments. According to studies performed in animals and cell cultures increased concentrations of pro-inflammatory cytokines such as IL-6 and TNF-α as well as increased levels of hs-CRP lead to elevated protein degradation through proteasome activation and reduced muscle protein synthesis (MPS) via downregulation of the Akt-mTOR signaling pathway. However, evidence regarding the effects of inflammaging on skeletal muscle mass in humans is lacking. Thus, the present study will compare proteasome activation and the protein synthetic response in the fasted and postprandial period between older adults with increased systemic inflammation and their healthy control counterparts.
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Systemic inflammation
Timeframe: At baseline.
Change in muscle protein synthesis (MPS)
Timeframe: At baseline and 180 min following protein ingestion.
Change in intracellular signaling proteins in muscle
Timeframe: At baseline and 180 min following protein ingestion.
Change in proteasome activities in muscle
Timeframe: At baseline and 180 min following protein ingestion.
Change in protein expression level of proteasome subunits
Timeframe: At baseline and 180 min following protein ingestion.