Effect of Reducing Sedentary Behavior on Blood Pressure (NCT03307343) | Clinical Trial Compass
CompletedNot Applicable
Effect of Reducing Sedentary Behavior on Blood Pressure
United States271 participantsStarted 2018-01-03
Plain-language summary
This is a 2-arm, 3-month randomized trial comparing a novel sedentary behavior intervention vs. control in working adults (n=271). The primary outcome is resting systolic blood pressure (SBP) at 3 months; secondary outcomes will be resting diastolic blood pressure (DBP), ambulatory blood pressure (ABP), and carotid-femoral pulse wave velocity (cfPWV). Also, best practice objective activity monitoring will be leveraged in the analysis of ABP to account for recent activity and posture and will inform adherence and dose-response relationships.We will also measure plasma renin activity and aldosterone as a potential mechanism of blood pressure reduction, and insulin and glucose as exploratory outcomes.
Who can participate
Age range21 Years – 65 Years
SexALL
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Inclusion criteria
✓. Age 21-65 years
✓. SBP 120-159 mmHg or DBP of 80-99
✓. Inactive (Engages in less than 150 min/wk of moderate + 2 x vigorous intensity physical activity)
✓. Currently perform deskwork for ≥ 20 hr/week at a desk compatible with the sit-stand attachment
✓. Employment within an approximate 25-mile radius of the University of Pittsburgh
✓. Stable employment (≥ 3 months in current job, plan to be in current job for the next 3 months)
✓. Supervisor approval to join the intervention
✓. Possession of a cellular phone able to receive text messages
Exclusion criteria
✕. SBP ≥ 160 mmHg, DBP ≥ 100 mmHg
✕. Use of antihypertensive or glucose controlling medication
. Comorbid condition that would limit ability to reduce sedentary behavior (e.g. musculoskeletal condition, current chemotherapy)
✕. History of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
✕. Unable to obtain consent from primary care provider or physician to participate
✕. Current use of sit-stand/standing desk, sedentary behavior prompting device, enrollment in a weight loss or exercise study or program, recent (\< 1 year) or planned bariatric surgery
✕. Currently pregnant or pregnant in that last 6 months; breastfeeding currently or in the last 3 months
✕. Plans to be away from your desk for an extended period (\>1 week) during the study period