Effect of Reducing Sedentary Behavior on Blood Pressure (NCT03307343) | Clinical Trial Compass
CompletedNot Applicable
Effect of Reducing Sedentary Behavior on Blood Pressure
United States271 participantsStarted 2018-01-03
Plain-language summary
This is a 2-arm, 3-month randomized trial comparing a novel sedentary behavior intervention vs. control in working adults (n=271). The primary outcome is resting systolic blood pressure (SBP) at 3 months; secondary outcomes will be resting diastolic blood pressure (DBP), ambulatory blood pressure (ABP), and carotid-femoral pulse wave velocity (cfPWV). Also, best practice objective activity monitoring will be leveraged in the analysis of ABP to account for recent activity and posture and will inform adherence and dose-response relationships.We will also measure plasma renin activity and aldosterone as a potential mechanism of blood pressure reduction, and insulin and glucose as exploratory outcomes.
Who can participate
Age range
21 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age 21-65 years
. SBP 120-159 mmHg or DBP of 80-99
. Inactive (Engages in less than 150 min/wk of moderate + 2 x vigorous intensity physical activity)
. Currently perform deskwork for ≥ 20 hr/week at a desk compatible with the sit-stand attachment
. Employment within an approximate 25-mile radius of the University of Pittsburgh
. Stable employment (≥ 3 months in current job, plan to be in current job for the next 3 months)
. Supervisor approval to join the intervention
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
. Possession of a cellular phone able to receive text messages
Exclusion criteria
. SBP ≥ 160 mmHg, DBP ≥ 100 mmHg
. Use of antihypertensive or glucose controlling medication
. Comorbid condition that would limit ability to reduce sedentary behavior (e.g. musculoskeletal condition, current chemotherapy)
. History of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
. Unable to obtain consent from primary care provider or physician to participate
. Current use of sit-stand/standing desk, sedentary behavior prompting device, enrollment in a weight loss or exercise study or program, recent (\< 1 year) or planned bariatric surgery
. Currently pregnant or pregnant in that last 6 months; breastfeeding currently or in the last 3 months
. Plans to be away from your desk for an extended period (\>1 week) during the study period