CompletedPhase 4

Sedative-Anxiolytic Effects on Simulated Driving Performance

United States15 participantsStarted 2017-09-15

Plain-language summary

This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving simulator to assess impairment.

Who can participate

Age range18 Years – 50 Years

SexALL

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Inclusion Criteria: * valid driver's license * english-speaking and literate Exclusion Criteria: * using daily medication for chronic condition * acute narrow angle glaucoma * previous adverse experience with study drugs * experiences motion sickness in response to driving simulator * BMI \> 30 * women who are pregnant, lactating, or planning on becoming pregnant * regular use of tobacco products * current substance use disorder * clinically significant ECG * current ongoing psychiatric disorder

What they're measuring

Standard Deviation of Lane Position (SLDP)

Timeframe: 16 hours

Trial details

NCT IDNCT03297944

SponsorMarion Coe

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-10-25

Results submitted2019-10-31

View on ClinicalTrials.gov More Psychomotor Impairment trials