In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste

Inclusion Criteria: * Evidence of a personally signed and dated informed consent. * Male and female participants who, at the time of screening, are between the ages of 18 and 65 years, inclusive. * Participant who is willing and able to comply with scheduled visits, treatment plan, and other study procedures. * Good general and mental health with, in the opinion of the investigator or medically qualified designee. No clinically significant and relevant abnormalities in medical history or oral examination. * Male participant able to father children and female participant of childbearing potential and at risk for pregnancy must agree to use a highly effective method of contraception throughout the study and for 5 days after the last dose of assigned treatment. * Good oral health without lesions of the oral cavity that could interfere with the study evaluations. * Maxillary dental arch suitable for the retention of the palatal appliance * Unstimulated salivary flow rate of at least 0.2 mL/minute and a stimulated salivary flow rate of at least 0.8 mL/minute. * Understands and is willing, able and likely to comply with all study procedures and restrictions. Exclusion Criteria: * Participants who are investigational site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or participants who are GSK employees directly involved in the conduct of the study. * Participation in other studi…