Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis

Inclusion Criteria: * Males and Females, 18 to 65 years of age (committed to consistent use of an acceptable method of birth control as described in Section 10). * In good general health as determined by a thorough medical history and physical examination, and vital signs. * Nonsmoker or ex-smoker (stopped \>1 year prior to study entry). * Subjects willing and able to provide written informed consent. * Is willing and able to comply with the requirements of the protocol and must be available for the full duration of the study. * For Part 1, subjects asymptomatic from any seasonal or perennial allergens. * For Part 1, elevated systolic blood pressure greater than 120 but less than 160 and never been on antihypertensive medications or have been off any hypertensive treatment for a period of 12 weeks or longer. * For Part 2, subjects with a well-documented history of seasonal allergic rhinitis (specifically ragweed pollen) with documentation of sensitivity by positive skin testing and/or IgE testing to the relevant allergens 12 months prior to enrollment that correlate with clinical history. * For Part 2, a ragweed positive skin prick test with a wheal diameter at least 5 mm larger than the negative control and/or a ragweed specific IgE greater or equal to 0.7 kU/L. * For Part 2, subjects with confounding allergies, or sensitization to cat epithelia, dog epithelia, Dermatophagoides farinae, or Dermatophagoides pteronyssinus or prevalent and relevant seasonal allergens as per th…