Lifestyle Change for Better Health (NCT03286699) | Clinical Trial Compass
TerminatedNot Applicable
Lifestyle Change for Better Health
Stopped: Due to challenges with recruitment, we were unable to complete recruitment as planned during the period we had funding to do so.
United States8 participantsStarted 2017-06-01
Plain-language summary
The goal of the research is to provide a first critical test of the novel scientific idea that a combined diet and exercise intervention may ameliorate shortening of leukocyte telomere length (LTL) in individuals with histories of successfully treated non-metastatic bladder cancer (BC) or colorectal adenoma (CRA) compared to a diet only intervention.
Who can participate
Age range18 Years – 84 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* BMI between 25.0 to \<40 kg/m2 (allows for use of assessments such as DXA to be included)
* History of histologically confirmed bladder cancer (non-metastatic) or colorectal adenoma
* Under clinical surveillance with no evidence of disease
Exclusion Criteria:
* WHO performance status 3-4 or deemed physically unable to participate by physician
* Currently pregnant or breastfeeding, were pregnant in the previous 6 months or breastfeeding in the previous 3 months, or planning pregnancy in the next year
* History of bariatric surgery
* Medical condition that could affect body weight (e.g., diabetes mellitus, hyperthyroidism, uncontrolled hypothyroidism, chronic renal insufficiency, chronic liver disease, gastrointestinal disorders including ulcerative colitis)
* Cancer diagnosis (other than bladder cancer or non-melanoma skin cancer) in the previous 5 years
* Current congestive heart failure, signs or symptoms indicative of an increased acute risk for a cardiovascular event
* History of myocardial infarction, coronary artery bypass or angioplasty, conditions requiring chronic anticoagulation (recent or recurrent DVT)
* Resting systolic blood pressure of \>160 mmHg or diastolic blood pressure \>100 mmHg
* Eating disorder that would contraindicate weight loss or physical activity
* Alcohol or substance abuse
* Current treatment for psychiatric issues (e.g., depression, bipolar disorder) or taking daily or extended release psychotropic medications in the pre…
What they're measuring
1
Leukocyte telomere length (LTL) at the 6 month assessment (controlling for appropriate covariates)
Timeframe: Blood samples will be collected as part of the 6 month assessment