Levomilnacipran in Healthy Males

Inclusion Criteria: * Male participants between 18 and 40 years-old * Written informed consent signed by the participant Exclusion Criteria: * Lifetime personal history of diagnosis of major depressive disorder according to the DSM-V (American Psychiatric Association, 2013) using the Structured Clinical Interview for DSM-V Axis I Disorders, Research Version, Non-patient Edition (SCID-5-RV for DSM-V; First et al., 2015) * A history of suicidal ideation and behaviour, including self-harm and/or harm to others. * A history of substance abuse and/or dependence. * A positive drug screen for illicit drugs * Substantial alcohol use * Current use of Monoamine Oxidase Inhibitors (MAOIs), including the antibiotic linezolid and the thiazine dye methylthioninium chloride (methylene blue) * Current use of serotonin-precursors (such as L-tryptophan, oxitriptan) * Current use of serotonergic drugs (triptans, certain tricyclic antidepressants, lithium, tramadol, St. John's Wort) * Concomitant use of NSAIDS, ASA, and other anticoagulants. * Current use of Thioridazine * Current use of CYP1A2 Inhibitors * Current use of Triptans (5HT1 Agonists) * Blood pressure greater than 140/90 and/or a pulse rate greater than 90 bpm * Recent history of myocardial infarction, cerebrovascular accident, cardiac arrhythmias, or unstable heart disease. * Evidence of significant physical illness contraindicating the use of levomilnacipran and duloxetine found on the physical exam or in the laboratory data obt…