Mental Ability Challenge Study in Adults With and Without HIV (NCT03244488) | Clinical Trial Compass
CompletedNot Applicable
Mental Ability Challenge Study in Adults With and Without HIV
United States22 participantsStarted 2015-12
Plain-language summary
It is estimated that by 2016, nearly 50% of HIV-positive individuals in the US will be aged 50 or older, and up to 60% of those will experience some degree of cognitive impairment as they age. The purpose of this study is to evaluate the contribution of the neuronal cholinergic receptor system to the cognitive impairments seen in adults aging with chronic HIV Infection. By using anti-cholinergic challenge drugs to reversibly "stress" cognitive functioning, the investigators hope to understand whether the presence of the HIV virus in the brain impairs the neural system necessary for normal cognition, more than would be expected from normal cognitive aging.
Who can participate
Age range35 Years
SexALL
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Inclusion criteria
✓. 35 years of age or older;
✓. HIV-Positive (must be on ART's for at least 6 months, most recent viral load (within 6 months) \<50, CD4+ count \>200, must be diagnosed HIV-positive at least 5 years) or HIV-Negative, At-Risk Individuals
✓. Able and willing to give written informed consent
✓. Negative urine pregnancy test
✓. Adequate visual and auditory acuity to allow neuropsychological testing.
Exclusion criteria
✕. Unmanaged HIV Infection, identified by no current medication regimen or the presence of one or more AIDS-defining conditions
✕. Fagerstrom cigarettes per day (CPD) score of '2' indicating heavy use of nicotine
✕. An ART regimen including a Protease Inhibitor Medication
✕. A documented history of cardiac disease or abnormal ECG at Screening