A Study Examining the Medication Apremilast as Treatment for Chronic Itch

Inclusion Criteria: Key Inclusion Criteria: A subject who meets all of the following criteria may be included in the study: * Male and non-pregnant, non-lactating female subjects aged 18 years or older * Diagnosed with chronic idiopathic pruritus (CIP) with an NRS Itch Score of ≥ 7 at both Screening and Baseline * Diagnosis of CIP for at least 6 weeks prior to screening * Willingness to avoid pregnancy or fathering of children * Ability and willingness to provide written informed consent * Willing and able to comply with all study requirements and restrictions * Willing to not participate in any other interventional trial for the duration of their participation * Subjects must be in good health as determined by medical history, physical examination, electrocardiogram, clinical laboratory tests and vital signs * Failure of a course 2-week course of treatment with topical triamcinolone 0.1% ointment BID * Histopathological demonstration of skin eosinophils, mast cell activation, lymphocytic infiltration, and/or dermal edema Exclusion Criteria: Key Exclusion Criteria: A subject who meets any of the following criteria will be excluded from the study: * Chronic pruritus due to a defined primary dermatologic disorder (e.g., atopic dermatitis, psoriasis, etc.) * Patients with a prior diagnosis of excoriation disorder * Use of topical treatments for CIP (other than bland emollients) within 1 week of Baseline * Systemic immunosuppressive or immunomodulating drugs within 4 weeks o…