TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects

Inclusion Criteria: * Informed consent is obtained from the participant * The participant is 18 years of age or older * The participant has no diagnosis of alcoholism according to international guidelines * The participant has not undergone chemotherapy for any carcinoma AND The participant is at risk for hATTR due to two or more the factors listed below: * cardiomyopathy or polyneuropathy with no obvious etiology atypical Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) or Motor Neuron Disease (MND) * autonomic dysfunction * hypertrophic cardiomyopathy or heart failure with preserved ejection fraction Left Ventricular Hypertrophy (LVH) * bilateral carpal tunnel syndrome * spinal stenosis or spinal radiculopathy * gait disorders * ocular changes involving vitreous opacities * unexplained weight loss \>5kg * renal abnormalities * family history of hATTR * based on imaging or biopsy suspected for the wild type TTR (ATTR) and not genetically tested for hATTR OR • The participant is diagnosed with hATTR OR • The participant is a 1st or 2nd degree relative of the TTR positive subject Exclusion Criteria * Informed consent is not obtained from the participant * The participant is younger than 18 years of age * The participant has a diagnosis of alcoholism according to International guidelines * The participant has undergone chemotherapy for any carcinoma * The participant is not at risk for hATTR