COmprehensive Remote Ischemic Conditioning in Myocardial Infarction

Inclusion Criteria: * Suspected anterior STEMI: new ST-elevation \> 0.1 millivolt (mV) (≥ 0.2 mV in men or ≥ 0.15 mV in women in leads V2-V3) in \> two contiguous leads in V1-V6; new or presumed new left bundle branch block; * Symptom onset no more than 12 h before presentation and planned primary PCI; * Age 18 to 75 years; * Willingness and capability to provide informed consent. Exclusion Criteria: * Previous anterior myocardial infarction; * Previous coronary artery bypass graft (CABG); * Myocardial infarction or stroke within the previous 30 days; * Treatment with thrombolysis within the previous 30 days; * Cardiogenic shock; * Thrombolysis in myocardial infarction (TIMI) flow grade 2 or 3 at coronary angiography; * Coronary anatomy or mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation) warranting emergent surgery; * Inability to obtain TIMI flow grade ≥ 2; * Conditions precluding use of RIC (paresis of lower limb, known severe peripheral artery disease or evidence of lower limb ischemia, and etc.); * Life expectancy of less than 12 months due to non-cardiac disease such as known malignancy or other comorbid conditions; * Contraindications to CMR; * Treated with therapeutic hypothermia before admission; * Pregnancy and lactating women; * Participation in another interventional trial.