Treatment of Acute Pericarditis With Anakinra

Inclusion Criteria: * Age ≥12 years in presence of a parent able to provide consent or age \>18 years * First or recurrent episode of acute pericarditis, defined as the presence of at least 2 of the following: * Chest pain (suggestive of pericarditis and not explained by another condition) * Pericardial friction rub on physical exam * ST-segment elevation and/or PR depression on ECG * New or worsening pericardial effusion * Pain of moderate-to-severe intensity (pain score ≥6 on a scale of 0-10 where 0 is no pain at all and 10 is the worst pain ever experienced) at time on enrollment * Ability to provide written informed consent if 18 years or older or to provide assent in presence of parental consent if 12-17 years of age Exclusion Criteria: * Pericarditis due to known bacterial or fungal infection * Pericarditis due to known malignancy * Pericarditis after cardiac surgery * Tamponade or need for pericardiocentesis for diagnostic/therapeutic purposes * Pregnancy or breastfeeding * Hypersensitivity to anakinra, latex or products derived from Escherichia coli * Chronic pain syndrome or chronic use of analgesic drugs