NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management (NCT03222518) | Clinical Trial Compass
CompletedPhase 3
NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management
Tunisia1,500 participantsStarted 2017-03-01
Plain-language summary
The purpose of this study is to:
Compare the effect of paracetamol alone against NSAIDs alone against the association of paracetamol + NSAIDs in the treatment of traumatic pain.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age 18 years or older
* acute (\<24 hours) post traumatic pain of the extremity and requiring analgesic treatment upon discharge for pain with intensity \>3 on a visual numeric scale
Exclusion criteria:
* open fracture
* head, abdominal, thoracic or polytrauma.
* Need for hospitalization, regular use of paracetamol and NSAIDs during the two weeks before admission to ED
* history of allergy or hypersensitivity to either paracetamol or NSAIDs,
* contraindication to paracetamol or NSAIDs,
* acute /history of GI hemorrhage and renal insufficiency,
* an inability to assess pain intensity according to the VNS.
* Pregnancy
* heart failure
* known hepatic cirrhosis
* known severe renal impairment (Creatinine clearance \<30 ml/min)
* swallowing disorders
* Refusal, incapacity or difficulties to consent or to communicate