CompletedNot Applicable

The Effect of Lower Intraabdominal Pressure on Syndecan-1, sVEGF-R2, Occludin, KIM-1, and IL-6 on Living Donor Laparoscopic Nephrectomy

Indonesia44 participantsStarted 2017-08-01

Plain-language summary

This study aimed to evaluate the increase of intraabdominal pressure 12- 14 mmHg caused by pneumoperitoneum resulted from carbon dioxide (CO2) insufflation induce glycocalyx endothelial injury that cause kidney tubular injury on live donor patient that undergo laparoscopic nephrectomy surgery, and decreasing the intraabdominal pressure to 8-10 mmHg during surgery is expected to reduce the injury.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subjects aged 18-60 years old undergoing laparoscopic surgery, with American Society of Anesthesiologist (ASA) 1, body mass index 18-25. Patients who agreed to participate in this study and sign informed consent. Exclusion Criteria: * Subjects in the outside criteria of American Society of Anesthesia 1, body mass index \>25.

What they're measuring

Changes in Syndecan-1 level from baseline

Timeframe: 24 hours

Changes in sVGEFR-2 level from baseline

Timeframe: 24 hours

Changes in KIM-1 level from baseline

Timeframe: 24 hours

Changes in Interleukin-6 from baseline

Timeframe: 24 hours

Trial details

NCT IDNCT03219398

SponsorIndonesia University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-03-01

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