Autologous BMMNC Combined With HA Therapy for PAOD

Inclusion Criteria: * Patient age ≥ 20 * Patients with severe PAOD and diagnosed with Rutherford category 3, 4, or 5 * Contraindication to angioplasty or bypass surgery, or post-angioplasty or bypass surgery for once but with limited or no effect. * Patient without hypertension or hypertensive patient with adequate-controlled blood pressure. * With signed informed consent Exclusion Criteria: * Patient undergone any organ transplantation * Inability to undergo bone marrow aspiration * Pregnant woman * Life expectancy \< 1 year * Cognitive impairment * Active malignancy in 5 years prior to treatment * Bleeding diathesis or pulmonary embolism * Patient with active major cardiovascular diseases such as unstable angina, arrhythmia, heart failure, impaired cardiac function (ejection fraction \< 45%), or stroke * Estimated Glomerular Filtration Rate (eGFR) \< 30 * Glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) values higher than 80 U/L * Patient with severe diabetes mellitus (HbA1C \> 8%) * Patient with alcohol addiction * Patient with drug abuse * Patient with infections or skin disease on the ischemic leg. * Allergic to HA * Patient whose blockage region only occurred in the femoral artery or at foot.