Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive … (NCT03207100) | Clinical Trial Compass
CompletedNot Applicable
Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment
China338 participantsStarted 2017-12-06
Plain-language summary
This study evaluates safety and efficacy of analgesia-first minimal sedation as an early antihypertensive treatment for spontaneous intracerebral hemorrhage. The analgesia-first minimal sedation strategy relies on the remifentanil-mediated alleviation of pain-induced stress response and the antisympathetic activity of dexmedetomidine to restore the elevated blood pressure to normal level in patients with spontaneous intracerebral hemorrhage. This strategy allows rapid stabilization of blood pressure, and its use as a pre-treatment for patients on mechanical ventilation prior to painful procedures reduces blood pressure variability and thereby results in etiologic treatment. It is more effective in blood pressure control than conventional symptomatic antihypertensive treatment, reduces the incidence of early hematoma expansion and improves prognosis, ,lowers healthcare workers workload, increases patient adherence, and improves healthcare worker satisfaction.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Definitive diagnosis of ICH-induced acute brain injury by CT;
✓. Systolic BP ≥150 mmHg for at least twice;
✓. \>18 years old;
✓. Feasible for emergency antihypertensive treatment and real-time BP monitoring;
✓. Disease onset is within 24h;
✓. ICU or stroke unit admission within 24h.
Exclusion criteria
✕. Subject has contraindications for emergency intensified antihypertensive treatment;
✕. Intracranial hemorrhage secondary to intracranial tumor, recent trauma, cerebral infarction and thrombolytic therapy;
✕. History of ischemic stroke within 30 days before disease onset;
✕. Clinical or imaging examination reveals an expected high mortality in subject within the next 24h;
What they're measuring
1
Systolic BP control rate at 1h post-treatment initiation