Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study

Inclusion Criteria: * Patients after roux-y-gastric bypass or biliopancreatic diversion with documented hypoglycemia, i. e. ≤ 2.5 mmol/l and hypoglycaemic symptoms. * For subjects with reproductive potential, willingness to use contraceptive measures adequate to prevent the subject or the subject's partner from becoming pregnant during the study Exclusion Criteria: * Signs of current infection * Use of any investigational drug in the last four weeks prior to enrolment * Use of any anti-diabetic drugs * adrenal insufficiency and/or substitution with glucocorticoids * Neutropenia (leukocyte count \< 1.5 × 109/L or absolute neutrophil count (ANC) \< 0.5 × 109/L) * Anemia (hemoglobin \< 11 g/dL for males, \< 10 g/dL for females) * Clinically significant kidney or liver disease (creatinine \> 1.5 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \> 2 × ULN, alkaline phosphatase \> 2 × ULN, or total bilirubin \[tBili\] \> 1.5 × ULN) * Current immunosuppressive treatment or documented immunodeficiency * Uncontrolled congestive heart failure * Uncontrolled malignant disease * Currently pregnant or breastfeeding * known lactose intolerance