Active — Not RecruitingNot Applicable

Transcranial Direct Current Stimulation for Cognitive Improvement in Parkinson's Patients

United States40 participantsStarted 2015-10-19

Plain-language summary

The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left dorsolateral prefrontal cortex (LDLPFC) will induce long-lasting effects in improving cognitive function and reducing cognitive fatigue and fatigability in PD patients.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical diagnosis of PD with at least two of the four diagnostic criteria for PD (tremor, rigidity, bradykinesia, and postural instability) * Meets criteria for MCI (21 ≤ MOCA scores ≤ 26) * Must be able to consent Exclusion Criteria: * Patients with dementia (MOCA \< 21) * PD treatment using deep brain stimulation (DBS) * Diagnosis of psychosis * Diagnosis of multiple sclerosis * Diagnosis of stroke * Diagnosis of epilepsy * Diagnosis of chronic obstructive pulmonary disease * Diagnosis of congestive heart failure * Diagnosis of renal failure * Participants not fluent in English

What they're measuring

Change in Reaction Time (RT) on contextual cueing computer task

Timeframe: 90 minutes; pre-test during the second research visit, post-test on 6th research visit after 5 consecutive days of tDCS, a follow up test on the 7th research visit, 7 days after last tDCS session and 8th visit 14 days after last tDCS session

Trial details

NCT IDNCT03191916

SponsorSanford Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-07

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