Cognitive Impairment in Pediatric Onset Multiple Sclerosis
36 participantsStarted 2015-09-15
Plain-language summary
Computer-assisted rehabilitation of attention deficits in pediatric Multiple Sclerosis and ADHD patients recruited during the study "Cognitive impairment in Pediatric Onset Multiple Sclerosis: research of biomarkers predictive of cognitive impairment progression".
Who can participate
Age range
17 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* POMS diagnosed according to the most recent diagnostic criteria;
* age \<18 years;
* Expanded Disability Status Scale (EDSS) score ≤5.5;
* impairment on at least 2/4 attention tests defined as scores \<1.5 standard deviation (SD) of normative values;
* ADHD patients with the subtype inattention;
* ADHD diagnosis performed according the DSM-5 criteria and the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention- Deficit/Hyperactivity Disorder (MTA) - Swanson, Nolan, and Pelham IV Rating Scale (MTA-SNAP-IV), Conner's Parent Rating Scale Revised (CPRS-R), Conner's Teacher Rating Scale Revised (CTRS-R), Child Behavior Checklist (CBCL), Kiddie Schedule for Affective Disorder and Schizophrenia (K-SADS);
* age \<18 years;
* impairment on at least 2/4 attention tests defined as scores \<1.5 standard deviation (SD) of normative values;
Exclusion Criteria:
* severe cognitive impairment (performance ≤2.0 SD of normative values);
* severe visual loss (unable to read Times New Roman font 16 with the best correction);
* major psychiatric illness;
* alcohol or substance abuse;
* education \<5 years;
* previous cognitive rehabilitation training;
* ongoing relapse or steroid treatment during the 30 days preceding enrollment;
* ADHD subtype hyperactivity;
* previously exposure or treatment with any psychotropic drug.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
to evaluate the effect of the cognitive training on neuropsychological performances.