Cognitive Impairment in Pediatric Onset Multiple Sclerosis

Inclusion Criteria: * POMS diagnosed according to the most recent diagnostic criteria; * age \<18 years; * Expanded Disability Status Scale (EDSS) score ≤5.5; * impairment on at least 2/4 attention tests defined as scores \<1.5 standard deviation (SD) of normative values; * ADHD patients with the subtype inattention; * ADHD diagnosis performed according the DSM-5 criteria and the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention- Deficit/Hyperactivity Disorder (MTA) - Swanson, Nolan, and Pelham IV Rating Scale (MTA-SNAP-IV), Conner's Parent Rating Scale Revised (CPRS-R), Conner's Teacher Rating Scale Revised (CTRS-R), Child Behavior Checklist (CBCL), Kiddie Schedule for Affective Disorder and Schizophrenia (K-SADS); * age \<18 years; * impairment on at least 2/4 attention tests defined as scores \<1.5 standard deviation (SD) of normative values; Exclusion Criteria: * severe cognitive impairment (performance ≤2.0 SD of normative values); * severe visual loss (unable to read Times New Roman font 16 with the best correction); * major psychiatric illness; * alcohol or substance abuse; * education \<5 years; * previous cognitive rehabilitation training; * ongoing relapse or steroid treatment during the 30 days preceding enrollment; * ADHD subtype hyperactivity; * previously exposure or treatment with any psychotropic drug.