Motivation and Methylphenidate (NCT03190681) | Clinical Trial Compass
CompletedEarly Phase 1
Motivation and Methylphenidate
France35 participantsStarted 2017-07-11
Plain-language summary
The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.
Who can participate
Age range18 Years – 50 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* weight\>= 50kg and \<=90kg
* free and informed consent
* social security affiliation
* no chronic illness
* no previous participation to a protocol wth similar tasks
* no special legal status (guardianship,trusteeship)
* no personnal or familial neurologic or psychiatric background
* no contraceptive device for a reproductive woman
Exclusion Criteria:
* inability to squeeze a handgrip
* smoking
* psychoactive substance consumption less than 3 weeks ago
* pregnant or breastfeeding woman
* hypersensitivity to methylphenidate
* hyperthyroidism
* cardiovascular or cerebrovascular disease
* respiratory, hepatic or renal failure
* glaucoma
* pheochromocytoma
* gluten intolerance or hypersensitivity
* galactosemia, glucose malabsorption syndrome, lactase deficit
* countraindicated meds (IMAO, IMAO-A, orhtosympathomimetics, alcaloids, linezolin, enzymatic inducers, psycho-active drugs)