Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea

Inclusion Criteria: * Diagnosed OSA or suspected OSA based on snoring Exclusion Criteria: * Severe co-morbidities (cardiovascular, renal, lung disease, neurological), including: Congestive heart failure, Neurological conditions that may affect sleep or breathing (e.g. neuromuscular diseases e.g. myasthenia gravis; neurodegenerative diseases e.g. Alzheimer's/Parkinson's) * Medications that will substantially affect respiration, including opioids, barbiturates, theophylline, doxapram, acetazolamide, pseudoephedrine * Claustrophobia * Insomnia and other non-respiratory sleep disorders * Inability to sleep supine * Contraindications to oral appliances, including insufficient teeth to support the device, periodontal problems inducing tooth mobility, active temporomandibular joint disorder * Allergy to lidocaine or oxymetazoline HCl