This study will find out if analysing heartbeat in babies with brain injury, based on standard clinical monitors, can inform treatment decisions and monitor stress levels in real time
Who can participate
Age range0 Hours – 6 Hours
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
HIE COHORT
Inclusion Criteria:
* Full term babies (\>36 weeks)
* Requiring resuscitation at birth due to perinatal asphyxia and/or 5 minute Apgar score \<6.
* Structured clinical neurological examination (modified Sarnat stage) within six hours of age suggestive of encephalopathy (mild, moderate or severe)
* Age less than six hours at the time of admission to the neonatal unit
Exclusion Criteria:
* Babies with lethal congenital malformations or cardiac conditions that could affect heartbeat variability
* Participation in any controlled trials of investigational medical products (C-TIMPS)
HEALTHY COHORT
Inclusion criteria:
* Healthy full term babies (\>36 weeks) and birth weight between 9th to 91st centile
* Age less than six hours at the time of study enrolment
Exclusion criteria
* Babies requiring any medication or phototherapy
* Perinatal maternal fever
What they're measuring
1
Prognostic accuracy of HRV to predict adverse neurodevelopment outcome