This study aims to evaluate the safety, tolerability, pharmacodynamic, and pharmacokinetic (PK) of nemtabrutinib (formerly ARQ 531) tablets in selected participants with relapsed or refractory hematologic malignancies. No formal hypothesis testing will be performed for this study.
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Phase 1: Number of Participants Experiencing Dose Limiting Toxicity (DLT)
Timeframe: Cycle 1 (up to 28 days)
Phase 1: Number of Participants Who Experienced an Adverse Event (AE)
Timeframe: Up to approximately 86 months
Phase 1: Number of Participants Who Discontinued Study Treatment Due to an AE
Timeframe: Up to approximately 86 months
Phase 2: Expansion Cohorts A, B & C: Objective Response Rate (ORR) per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Criteria as Assessed by the Investigator
Timeframe: Up to approximately 64 months
Phase 2: Expansion Cohorts A, B, C: ORR per Lugano Classification as Assessed by the Investigator
Timeframe: Up to approximately 64 months