Trial Comparing EUS-guided Radiofrequency Ablation vs. EUS-guided Celiac Plexus Neurolysis
United States28 participantsStarted 2017-04-24
Plain-language summary
Pancreatic cancer is the second most common gastrointestinal malignancy. Abdominal discomfort is a main symptom in patients with pancreatic cancer. Approximately 75% have pain at diagnosis and over 90% in advanced stages. Pain control is an important part of the plan of care for patients with pancreatic cancer.. The celiac plexus is a group of nerves that supply organs in the abdomen. EUS-guided celiac plexus neurolysis (EUS-CPN) has been widely used for pain management in patients with pancreatic cancer. Radiofrequency ablation of celiac ganglia or celiac plexus (EUS-RFA) is also being performed to alleviate abdominal pain in pancreatic cancer patients. However currently no comparative studies exist comparing EUS-CPN with EUS-RFA. The purpose of the study is to compare EUS-CPN with EUS-RFA for pain management in pancreatic patients, in order to determine which technique is better at improving pain in pancreatic cancer patients.
Who can participate
Age range19 Years
SexALL
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Inclusion criteria
✓. Age ≥ 19 years
✓. The subject is capable of understanding and complying with protocol requirements.
✓. The subject is able to understand and willing to sign an informed consent form prior to the initiation of any study procedures.
✓. Abdominal pain typical for pancreatic cancer
✓. Cross-sectional imaging findings consistent with pancreatic cancer
✓. Pancreatic cancer confirmed by EUS-FNA in patients referred for suspected pancreatic cancer OR Patients with known diagnosis of pancreatic cancer
✓. Inoperable pancreatic cancer as determined during EUS or prior CT
Exclusion criteria
✕. Age \<19 years
✕. Unable to obtain consent for the procedure from the patient
✕. Previous CPN or other neurolytic block that could affect pancreatic cancer-related pain or had implanted epidural or intrathecal analgesic therapy
✕. Another cause for abdominal pain such as pseudocyst, ulcer or other intraabdominal disorder
✕. Pregnant women will be excluded. This will be confirmed by self-report. Pregnancy in females of childbearing potential will be determined by routine preoperative urine or serum Human Chorionic Gonadotropin (HCG) testing.