Single Bolus Recombinant Nonimmunogenic Staphylokinase (Fortelyzin) and Bolus Infusion Alteplase in Patients With AIS

Inclusion Criteria: * Men and women between the ages of 18 and 80 (Version 1.0) * Men and women aged 18 years and older, after 80 years with caution (Version 2.0) * Verified diagnosis of ischemic stroke (from 5 to 25 points on the NIHSS scale). (Version 1.0) * Verified diagnosis of ischemic stroke (Version 2.0) * The time from the onset of the disease is no more than 4.5 hours. * Informed consent received Exclusion Criteria: * The time of the onset of the first symptoms is more than 4.5 hours from the onset of the disease or the time of the onset of the first symptoms of a stroke is not known (for example, the development of a stroke during sleep - the so-called "night stroke"). * Increased sensitivity to alteplase, gentamicin (residual traces from the production process). * Systolic blood pressure above 185 mm Hg. Art. Or diastolic blood pressure above 110 mm Hg. Art. Or the need for / in the administration of drugs to reduce blood pressure to these boundaries. * Neuroimaging (CT, MRI) signs of intracranial hemorrhage, brain tumors, arteriovenous malformation, brain abscess, aneurysm of cerebral vessels. * Surgery on the brain or spinal cord. * Suspicion of subarachnoid hemorrhage. * Signs of severe stroke: clinical signs (stroke scale NIH\> 25), neuroimaging (according to CT of the brain and / or MRI of the brain in the DWI, the ischemia focuses on the territory of more than 1/3 of the CMA pool). * Simultaneous reception of oral anticoagulants, for example, warfarin with…