Active — Not RecruitingPhase 1

Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects

United States30 participantsStarted 2017-10-24

Plain-language summary

The main purpose of this study is to examine the effect of prolonged (72 hour) administration of glucagon compared to placebo on energy expenditure in healthy, non-diabetic, obese subjects.

Who can participate

Age range18 Years – 55 Years

SexALL

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Inclusion criteria

✓. fasting plasma glucose \<126 mg/dL \[7.0 mmol/L\] and
✓. HbA1c \<6.5% \[48 mmol/mol\]) and
✓. in good health on the basis of medical history, physical examination (PE), electrocardiogram (ECG), and normal laboratory values obtained from Screening visit labs.

What they're measuring

Energy Expenditure

Timeframe: 24 hours

Effects of continuous IV infusion of glucagon versus placebo

Timeframe: 72 hours

Trial details

NCT IDNCT03139305

SponsorAdventHealth Translational Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-02-14

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