Metoprolol to Reduce Perioperative Myocardial Injury
United States72 participantsStarted 2016-12
Plain-language summary
The purpose of this research study is to test if a commonly used, FDA-approved medication, called metoprolol, given at the conclusion of anesthesia following surgery, and during postoperative admission, reduces the possibility of heart related complications in patients with coronary artery disease (CAD).
Who can participate
Age range50 Years
SexALL
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Inclusion criteria
✓. Age \>= 50 years
✓. Beta-blocker naïve \[30 days prior to surgery\]
✓. Previously diagnosed coronary artery disease (CAD), or
✓. History of peripheral vascular disease (PVD), or
✓. Chronic kidney disease (CKD) \[eGFR ≤60ml/min\], or
✓. History of positive stress test or
✓. At high risk for CAD (must meet at least 2 criteria):
✓. Major non-cardiac, elective surgery under general anesthesia
Exclusion criteria
✕. History of stroke, or transient ischemic attack (TIA)
✕. Previously diagnosed carotid disease, i.e., either 70% unilateral or 50% bilateral carotid occlusion.
✕. Heart rate \<=55bpm
✕. Congestive heart failure with New York Heart Association(NYHA) Functional Classification of III-IV or left ventricular heart failure with ejection fraction ≤50%
✕. Severe valvular regurgitation
✕. Second or third degree atrioventricular (AV) block without pacemaker
What they're measuring
1
Effectiveness of Beta-blocker Therapy Reducing Post-operative Myocardial Injury