Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)

Inclusion Criteria: * Must meet Diagnostic and Statistical Manual of Mental Disorders-V (DSM- V) criteria for moderate to severe Alcohol Use Disorder (AUD), * Must produce positive urine toxicology screens on admission to study * Must demonstrate good health as verified by screening examination * Must be able to read English and complete study evaluations * Must be able to provide informed written and verbal consent Exclusion Criteria: * Meeting current use disorder for any other psychoactive substance, excluding nicotine. * Having any other current Axis I psychiatric disorders or medical conditions requiring treatment or medication * EKG evidence at baseline screening of any clinically significant conduction abnormalities including a Bazlett's QTc (corrected QT interval) of \>470 msec. * Must not be on monophasic contraceptives, nursing or pregnant.