Stopped: Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2.
This Phase Ib/II, open-label, multicenter, non-randomized, dose-escalation study will evaluate the safety, efficacy, and pharmacokinetics of obinutuzumab in combination with idasanutlin and venetoclax in participants with R/R FL and obinutuzumab or rituximab in combination with idasanutlin and venetoclax in participants with R/R DLBCL. The study will include an initial dose-escalation phase followed by an expansion phase. The dose-escalation phase is designed to determine the recommended phase II doses (RP2Ds) and regimen for idasanutlin and venetoclax in combination with obinutuzumab for FL participants and in combination with rituximab for DLBCL participants.
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RP2D of Idasanutlin When Given in Combination With Obinutuzumab or Rituximab
Timeframe: Cycle 1 Day 1 up to Cycle 2 Day 28 (each cycle = 28 days)
RP2D of Venetoclax When Given in Combination With Obinutuzumab or Rituximab
Timeframe: Cycle 1 Day 1 up to Cycle 2 Day 28 (each cycle = 28 days)
Percentage of Participants With Dose-Limiting Toxicities (DLTs)
Timeframe: Cycle 1 Day 1 up to Cycle 2 Day 28 (each cycle = 28 days)
Percentage of Participants With Adverse Events (AEs)
Timeframe: From Baseline up to approximately 48 months
Percentage of Participants With Complete Response (CR), Determined by an Independent Review Committee (IRC) on the Basis of Positron Emission Tomography-Computed Tomography (PET-CT) Scans Using Modified Lugano 2014 Criteria
Timeframe: At end of Induction (EOI) (within 6 to 8 weeks after Cycle 6 Day 1 [up to approximately 28 weeks] [each cycle = 28 days])