Exercise Regulation of Human Adipose Tissue

Inclusion Criteria: * Age: 25-55 years old at the time of screening * Body mass index (BMI) must be: * ≥20 and ≤ 27 kg/m2 for lean subjects * ≥25 and ≤ 37 kg/m2 for subjects with type 2 diabetes * ≥27 and ≤ 37 kg/m2 for obese/overweight subjects * HbA1c values: * ≤5.7 ± 0.1% for lean and overweight/obese subjects * 6.5 ± 0.1% - 9.0 ± 0.1% for subjects with type 2 diabetes Exclusion Criteria: * Age \<25 and \>55 years old * Type 1 Diabetes * HbA1c ≥ 9.0% * Heart or lung disease * Basal-Bolus Insulin regimen * Use of beta-blockers or thiazolidinediones * Acute systemic infection accompanied by fever, body aches, or swollen lymph glands * BMI ≥ 37 kg/m2 * Current dieting or weight loss efforts * Current pregnant or breastfeeding * Known history of HIV/AIDS or certain cancers * Biochemical evidence of renal or hepatic dysfunction; renal or liver disease * Demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis * Recent blood donation * Clinical history of stroke * Severe hypertension (systolic \> 160 mmHg or diastolic \> 90 mmHg) * Inability to exercise at 50% of predicted heart rate (HR) reserve at baseline * Participants who screen positive for The American Heart Association's contraindications to exercise testing * History of keloid formation