Platelet-rich Plasma Combined With Conventional Surgery in the Treatment of Atrophic Nonunion of Femoral Shaft Fractures

Inclusion Criteria: * Femoral shaft fractures * Fracture time is more than 9 months * X-ray reveals gap and sclerosis at the fracture ends, medullary closure, osteoporosis, with the absence of trabecular bone formation among callus, and for more than 3 months * Magnetic resonance imaging reveals widened gap and atrophic fracture ends, a small amount or even no callus formation * Histological examination reveals that the gap at the fracture ends is filled with fibrous tissue without osteogenic activity * Age of 18-70 years Exclusion Criteria: * The underlying disease that affects wound healing, such as diabetes, hematological system diseases, immune diseases, connective tissue diseases * Pregnancy or lactation * Heart, lung, liver, and kidney dysfunction * Participate in other clinical trials