CompletedNot Applicable

Multi-center Trial of Goal-directed Fluid Management Based on Pulse Pressure Variation Monitoring

256 participantsStarted 2007-06-01

Plain-language summary

Background: Intraoperative fluid therapy guided by mechanical ventilation-induced pulse-pressure variation (PPV) may improve outcomes after major surgery. It was tested this hypothesis in a multi-center study. Methods: The patients were included in two periods: a first control period (control group; n=147) in which intraoperative fluids were given according to clinical judgment. After a training period, intraoperative fluid management was titrated to maintain PPV\< 10% in 109 surgical patients (PPV group). It was performed 1:1 propensity score matching to ensure the groups were comparable with regard to age, weight, duration of surgery, and type of operation. The primary endpoint was postoperative hospital length of stay.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * high-risk patients undergoing open major surgery under general anesthesia and who required ICU admission postoperatively Exclusion Criteria: * Patients with severe aortic regurgitation, cardiac arrhythmias, congestive heart failure, patients undergoing renal replacement therapy, those undergoing palliative surgery were excluded from the study.

What they're measuring

postoperative length of stay

Timeframe: up to 90 days

Trial details

NCT IDNCT03128190

SponsorInstituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-06-01

View on ClinicalTrials.gov More Goal-directed Fluid Therapy trials