High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period (NCT03121482) | Clinical Trial Compass
CompletedNot Applicable
High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period
France650 participantsStarted 2017-04-20
Plain-language summary
Prospective multicenter randomized controlled open-label trial comparing 2 strategies of oxygenation during the post-extubation period in ICU patients at high risk of extubation failure. Patients will be randomized and assigned to one of the two groups, with a 1:1 ratio.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Duration of mechanical ventilation prior to extubation at least 24h
* Planned extubation decided by the physician in charge of the patient after success of a weaning trial
* Patients at high risk of reintubation according to the following criteria: patients older than 65 years, or those having any underlying chronic cardiac or lung disease.
Exclusion Criteria:
* Patient admitted for traumatic brain injury
* Periphal neuromuscular disease as reason for intubation
* Usual lon-term treatment with NIV for chronic desease
* Usual lon-term treatment with CPAP for obstructive apneas syndrome
* Contraindication to NIV
* Unplanned extubation
* Do-not-reintubated order at time of extubation
* Terminal extubation for end of life
* People under legal protection
* Opposition to participate