STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation

Inclusion Criteria: * A diagnosis of symptomatic paroxysmal AF with the following documentation: (1) physician's note indicating recurrent self- terminating AF or paroxysmal AF; and (2) any ECG documented AF within 6 months prior to enrollment. * Age 18-80 Exclusion Criteria: * History of AF treatment with class I or III antiarrhythmic drug, including sotalol, with the intention to prevent an AF recurrence. However, patients pretreated with above AAD for less than 7 days with the intention to convert an AF episode are allowed. * Prior persistent AF (cardioversion after 48 hours or continuous AF that is sustained \>7 days) * Left atrial diameter greater than 5.0 cm * Prior left atrial ablation or left atrial surgical procedure * Presence or likely implant of a permanent pacemaker, biventricular pacemaker, loop recorder, or any type of implantable cardiac defibrillator (with or without biventricular pacing function) * Body mass index (BMI) \>35 kg/m2 * Presence of any pulmonary vein stents * Known presence of any pre-existing pulmonary vein stenosis * Pre-existing hemidiaphragmatic paralysis * Presence of any cardiac valve prosthesis * Moderate or severe mitral valve regurgitation or stenosis * Any cardiac surgery, myocardial infarction, percutaneous coronary intervention/ percutaneous transluminal coronary angioplasty or coronary artery stenting which occurred during the 90 day interval preceding the date the subject signed the Informed Consent Form * Unstable angina * New …