Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds (ADSCs-BWs)

Inclusion Criteria: * Male and female aged 18-65 years; * Patients with 2-nd B and 3-d degree burn wound; * Body surface area involved in burns - from 10 to 50%; * The area of skin grafting - less than 6% of the skin surface; * Burn occurring within the 24 hours prior to the hospitalization; * Adequate antishock therapy in the prehospital phase; * Women of childbearing age to provide proof of a current, valid negative pregnancy test; * Confirmation of participation in the study by signing the Instrument of Consent, personally or through a responsible caretaker. Exclusion Criteria: * Prognostically favorable or unfavorable outcome of the disease * (Lesion Severity Index, less than 30 or more, than 120 score); * Combined trauma; * Severe respiratory tract burn injuries; * Ischemic disease of the lower extremities; * The presence of cardiovascular disease (CVD): symptoms of unstable angina, myocarditis, heart disease, heart failure; * History of prior cancer; * Healing of duodenal or gastric ulcers in history; * Diabetes * Severe chronic liver diseases or kidney disease in history; * History of alcohol or other drug abuse; * Pregnanсy; * Any other physical diseases in decompensation or subcompensation, * or those that are rated as severe or moderate; * Therapeutic issues or psychiatric disorders of a patient which would * make the subject unsuitable to participate in this study or to complete it; * Participation in another clinical trial