WithdrawnNot Applicable

Modulating Oscillations and Working Memory in Patients With Subdural Electrodes

Stopped: Record erroneously created as an updated trial was initiated \& performed in the same patient population.

0Started 2014-01

Plain-language summary

Purpose: To investigate whether rhythmic direct electrical stimulation (DES) causes entrainment of endogenous neural oscillatory activity and whether such activity improve cognition. Participants: Drug-resistant epilepsy patients undergoing epilepsy surgery cortical mapping with continuous electrocorticography (ECoG) with intracranial electrodes. Procedures (methods): Rhythmic electrical stimulation will be delivered via intracranial electrodes during routine extra-operative cortical mapping. Long-term ECoG, Pre-stimulation ECoG, peri-stimulation ECoG, and post-stimulation ECoG data will be analyzed to assess for entrainment of neural oscillations.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. History of medically intractable epilepsy
✓. Capable of giving informed consent
✓. Aged 18 - 80 years, either sex

Exclusion criteria

✕. Past or current history of other neurological illnesses including ischemic stroke, intracerebral hemorrhage, brain neoplasm.
✕. Major systemic illness
✕. Severe cognitive impairment defined as mini-mental state examination of less than 20
✕. Severe psychiatric illness
✕. Excessive use of alcohol or other substances

What they're measuring

Working Memory Task Performance - Accuracy

Timeframe: 1 Hour

Working Memory Task Performance - Reaction Time

Timeframe: 1 Hour

Trial details

NCT IDNCT03111290

SponsorUniversity of North Carolina, Chapel Hill

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-03-15

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