Liposome Bupivacaine for WRIST Blocks

Inclusion Criteria: * Male or female, at least 18 years and max 85 years of age at screening * Scheduled to undergo Dupuytren's contracture release * American Society of Anesthesiologists (ASA) physical status I, II or III * Able to demonstrate sensory function by exhibiting sensitivity to cold, pinprick and light touch * Female subjects must be surgically sterile or have a monogamous partner who is surgically sterile; at least 2 years postmenopausal; or practicing abstinence; or using an insertable, injectable, transdermal, or combination oral contraceptive approved by the FDA for greater than 2 months prior to screening and commit to the use of an acceptable form of birth control for the duration of the study and for 30 days after completion of the study * Able to understand the English or Dutch language, purpose and risks of the study * Able to provide informed consent and authorization to use protected health information, adhere to the study visit schedule and complete all study assessments Exclusion Criteria: * Currently pregnant, nursing or planning to become pregnant during the study or within 1 moth after study drug administration * History of hypersensitivity to local anesthetics * Contraindication to bupivacaine, paracetamol, ketorolac, oxycodone or morphine * Medical condition that will make it difficult to assess sensory distributions of peripheral nerves or to communicate with staff * Chronic scheduled use of any of the following medications within the times s…