Cold Induced Activation of Brown Adipose Tissue in Humans (NCT03096535) | Clinical Trial Compass
CompletedNot Applicable
Cold Induced Activation of Brown Adipose Tissue in Humans
Denmark16 participantsStarted 2017-04-02
Plain-language summary
This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days. A secondary purpose is to make a validation of an infrared thermography camera by comparison of skin temperatures and SUV of the supraclavicular brown adipose tissue.
Who can participate
Age range18 Years – 30 Years
SexMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-30 years.
* Men
* Caucasian white
* Body Mass Index 19-25 kg/m2.
* Moderate physical activity level (not more than 8-10 hours of training pr. Week)
* Ability to give informed consent.
* Ability to follow verbal and written instructions in Danish.
* Body fat percent under 21% measured at the pre-examination day.
Exclusion Criteria:
* Chronic diseases: Hormonal: Metabolic Diseases mb. Graves, hypothyroidism, myxedema and goiter. Diabetes Melitus, Coronary heart disease (history of myocardial infarction, unstable angina pectoris, or congestive heart failure), cancer treated within last 3 years.
* Tobacco, marijuana or intravenous drug use within 1 year of screening.
* Dieting, recent weight loss (\>3 kg within 3 month) or a history of an eating disorder.
* Dietary supplements.
* History of depression, psychosis, or other psychiatric illness requiring hospitalization.
* Alcohol consumption \>14 units/week.
* History of alcohol abuse within the past 3 years.
* Known liver disease or elevated liver biomarkers more than 2 times upper normal levels in the preliminary investigation.
* Known kidney disease or elevated kidney biomarkers, eCRF \<60 ml/min, in the preliminary investigation.
* Use of daily medications, except for seasonal use of antihistamines.
* Diagnosed sleep disturbances.
* Pacemaker or other electronics implanted in the body.
* Magnetic impressionable metal implants or foreign objects in the body inconsistent with completion of MR.
* Cl…
What they're measuring
1
Difference in brown adipose tissue (BAT) activity after cooling versus no cooling.
Timeframe: Difference in SUV mean after 2 hours of cooling versus 2 hours of no cooling.