CompletedNot Applicable

MRI Differentiating Gut TB and Crohn's

China120 participantsStarted 2014-12-30

Plain-language summary

It is clinically challenging to differentiate Crohn's disease from gut tuberculosis especially in regions endemic of tuberculosis infection. The investigators plan to perform magnetic resonance enterography (MRE) who presented to our hospital in Shenzhen, China for new onset of lower gastrointestinal symptoms and ileocecal mucosal lesions of uncertain diagnosis as evidenced by the presence of inflammation, ulceration, strictures or nodules on colonoscopy. MRE findings will be independently interpreted by two radiologistsThe role of MRE in distinguishing gut tuberculosis from Crohn's disease will be determined.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * New-onset lower gastrointestinal symptoms of less than 3 months * Ileocecal mucosal lesions of uncertain diagnosis as evidenced by the presence of inflammation, ulceration, strictures or nodules on colonoscopy. * No prior tuberculosis treatment * No prior immunomodulatory or anti-tumor necrosis factor treatment Exclusion Criteria: * Stage 4 or 5 chronic kidney disease, i.e. a glomerular filtration rate of \<=30 ml/min. * Contraindications to magnetic resonance imaging, including the installation of metallic devices or implants in-situ (e.g. pacemakers) * Prior intestinal resection * Known concomitant chronic small / large bowel disease, including ulcerative colitis, eosinophilic gastroenteritis, NSAID-related enterography etc.

What they're measuring

Small / large bowel transmural enhancement

Timeframe: During procedure

Trial details

NCT IDNCT03096379

SponsorThe University of Hong Kong

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-12-30

View on ClinicalTrials.gov More Crohn Disease trials