TLC399 (ProDex) in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO) (NCT03093701) | Clinical Trial Compass
CompletedPhase 2
TLC399 (ProDex) in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO)
United States31 participantsStarted 2017-04-01
Plain-language summary
Randomized, double-masked trial designed to investigate the use of TLC399 (ProDex) in subjects with macular edema due to CRVO or BRVO.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. male or female, at least 18 years of age
. macular edema due to CRVO or BRVO
. best-corrected visual acuity (BCVA) score of 20/40 to 20/400
. mean central subfield thickness (CST) ≥350 um
. willing and able to comply with the study procedure and sign a written informed consent
. agree to use a medically acceptable form of birth control
Exclusion criteria
. poorly controlled diabetes
. history of significant intraocular pressure (IOP) elevation to steroid treatment
. history of ocular hypertension and glaucoma
. cataract surgery in the study eye within 3 months, or intraocular surgery within 6 months prior to screening
. use of hemodilution for the treatment of RVO
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of Subjects With BCVA Gain of 15 or More Letters From Baseline in the Study Eye