Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis

Inclusion Criteria: * diagnosis of GAgP (AAP, 1999); * presence of ≥20 teeth; * presence of ≥ 6 sites presenting PD ≥ 5mm with bleeding on probing (BOP) and ≥2 sites with PD ≥7mm (including incisors and first molars, in addition to other two non-contiguous teeth); * good general health; * agree to participate in the study and sign a written informed consent. All subjects will be individually informed about the objectives, probable risks and benefits of the protocol treatment (according to Resolution nº196 of October 1996 and to the Professional Code of Dental Ethics - 179/93). Exclusion Criteria: * pregnancy or lactating; * suffer from any systemic disease (e.g. cardiovascular disorders, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease; * took antimicrobials in the previous 6 months; * taking long-term anti-inflammatory drugs; * previous periodontal treatment within the last 12 months; * smoker ≥ 10 cigarettes.