Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis

Inclusion criteria * Diagnosis of generalized aggressive periodontitis (Armitage, 1999; American Academy of Periodontology, 2015); * Have undergone a first approach for periodontal treatment (full-mouth ultrasonic debridement); * Present at least one residual pocket of probing depth ≥ 5 mm and bleeding on probe not located in furcation region; * Good general health; * Agree to participate in the study and sign the informed consent form (TCLE) after explaining the risks and benefits; Exclusion Criteria * Systemic problems (cardiovascular alterations, blood dyscrasias, immunodeficiency - ASA III / IV / V) that contraindicate the periodontal procedure; * Have used antibiotics and anti-inflammatories in the last six months; * Smoke ≥ 10 cigarettes/day; * Pregnant or nursing; * Chronic use of medications that may alter the response of periodontal tissues; * Indication of antibiotic prophylaxis for dental procedures; * History of allergic reaction to acetylsalicylic acid, fish or seafood.