Biomarkers of Cytomegalovirus Fetal Infection and Disease

Inclusion Criteria: CMV cases: * Informed consent obtained from the mother; * Pregnant women either with a history of primary CMV infection in pregnancy or carrying a fetus with ultrasound features compatible with CMV infection and willing to have amniocentesis for fetal diagnosis of CMV infection Control cases : \- Pregnant women carrying a fetus with aneuploidy-dysgonosomy Exclusion Criteria: CMV cases: * Fetuses older than the 26 weeks of gestation at the time of diagnosis of HCMV infection or impossibility to collect foetal samples by the end of the 26th week of gestation * Mother unable to understand the protocol * Absence of informed consent * Any clinical rationale not to perform cordocentesis * Mother \<18 years age * Administration of immunoglobulins or anti-viral therapy to the mother before the collection of fetal samples or before the diagnosis of symptomatic fetal infection * Administration of anti-HCMV drugs to the foetus before the collection of fetal samples or before the diagnosis of symptomatic fetal infection * Administration of immunosuppressive drugs to the mother during pregnancy * Maternal auto immune disorders * Multiple pregnancies. Control cases : * Mother unable to understand the protocol * Absence of informed consent