Design and Validation of a New Assessment Tool for Lichen Planopilaris (NCT03082560) | Clinical Trial Compass
UnknownNot Applicable
Design and Validation of a New Assessment Tool for Lichen Planopilaris
United States40 participantsStarted 2017-02-10
Plain-language summary
The study's Primary Objective is to design and validate a grading system for objective and accurate assessment of lichen planopilaris.
Secondary Objectives:
* To assess change in symptoms such as pain and itch using a Numeric Rating Scale(NRS) scores and quality of life using the Dermatology Life Quality Index (DLQI) scores
* To correlate this grading system with patient skin biopsies evaluating disease activity on a microscopic level
* To correlate this grading system with digital global photography and trichoscopy
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Male or female subjects in general good health between the ages of 18 and 80 years old
✓. Clinical and histologic diagnosis of lichen planopilaris
✓. Subject is able to understand and sign informed consent
✓. Subject is able to complete the study and comply with study procedures
✓. Subject has no known allergy to non-toxic ink
✓. Subjects should be managed by an Massachusetts General Hospital dermatologist for their lichen planopilaris for the duration of the study
Exclusion criteria
✕. Presence of dermatoses that might interfere with LPP diagnosis and/or evaluation such as seborrheic dermatitis or psoriasis
✕. Other selected concomitant causes of hair loss, including discoid lupus erythematosus, central centrifugal cicatricial alopecia (CCCA), telogen effluvium
✕. Abnormal TSH laboratory value \>1 standard deviation above normal within last year
What they're measuring
1
Boston Grade of Activity in Lichen Planopilaris (Boston GOAL)