Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors (NCT03074513) | Clinical Trial Compass
Active ā Not RecruitingPhase 2
Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors
United States133 participantsStarted 2017-03-03
Plain-language summary
This phase II trial studies how well atezolizumab and bevacizumab work in treating patients with rare solid tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab and bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Signed informed consent form
* Ability to comply with the study protocol, in the investigator's judgment
* Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1; previously irradiated lesions can be considered as measurable disease only if progressive disease has been unequivocally documented at that site since radiation; the pleural mesothelioma cohort will require measurable disease according to modified RECIST
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L without granulocyte colony-stimulating factor support, obtained within 14 days prior to initiation of study treatment
* Lymphocyte count \>= 0.5 x 10\^9/L, obtained within 14 days prior to initiation of study treatment
* Platelet count \>= 100 x 10\^9/L without transfusion, obtained within 14 days prior to initiation of study treatment
* White blood cell (WBC) count \>= 2500/ul, obtained within 14 days prior to initiation of study treatment
* Hemoglobin \>= 90 g/L (patients may be transfused to meet this criterion), obtained within 14 days prior to initiation of study treatment
* Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) =\< 2.5 x upper limit of normal (ULN), obtained within 14 days prior to initiation of study treatment, with the following exceptions: patients with documented liver metastases: AST and ALT =\< 5 x ULN; pā¦